Unfortunately, even modern advanced medicine cannot diagnose many diseases in the early stages because they are easily confused with other diseases with similar symptoms. Ankylosing Spondylitis is the disease that is hard to catch because it can be mistaken as osteochondrosis. At first, a person suffers from pain in the back after sleeping or sitting. However, the pain disappears after some stretching or walking.
Non-steroidal anti-inflammatory drugs (NSAIDs) help to mask the painful symptoms of the disease. However, after a couple of months of NSAID medication, the pain gets worse as the back gets stiffer significantly limiting mobility. At this point, it is important to consult a doctor immediately.
Ankylosing Spondylitis is a chronic inflammatory disease of the musculoskeletal system characterized by a gradual ossification of the spine and joints. If left untreated, the vertebrae begin to fuse together and eventually form an unbending fusion leading to severe disability.
Also, ankylosing spondylitis can also cause such serious complications as renal failure, cardiovascular disease, respiratory and musculoskeletal disorders. The disease is considered to be rare affecting mostly men of the young and middle age. It is very uncommon for women to have it.
In most cases, disease starts in the area of the joints between the iliac bones and the sacrum and gradually progresses to the whole spine. As a result, a patient is unable to perform simple movements as he cannot bend or turn.
In the case of ankylosing spondylitis, immune cells attack intervertebral discs, tendons and ligaments of joints, causing the inflammation. As a result, the elastic tissues are gradually transformed into a solid bone limiting the mobility of the spine and joints.
Nowadays, the actual causes of the disease are not yet defined. Most experts believe that disease is autoimmune because people affected by ankylosing spondylitis are often carriers of HLA-B27 antigen, which is known for disruptions in the immune system. The disease can develop as a result of spinal trauma, hormonal disorders, hypothermia, and infectious diseases in acute or chronic forms, gastrointestinal and urogenital inflammatory diseases.
Most treatment methods for spondylitis are symptomatic. Mostly, the treatment reduces and eliminates the inflammatory autoimmune process in the joints and bones. It also alleviates pain. Usually, to manage pain patients often take non-steroidal anti-inflammatory drugs in general and Celebrex in particular.
Celebrex belongs to the class of non-steroidal anti-inflammatory therapy (NSAIDs). Its main active ingredient is celecoxib. It is known to be effective in treating chronic pain and inflammation and improve the quality of life of rheumatologic patients.
One of the most popular NSAIDs in the world, Celebrex is a highly selective COX-2 inhibitor. It has a proven history of over 15 years of clinical use with registration in 125 countries. To patients with ankylosing spondylitis, doctors recommend taking Celebrex in the dosage of 200 mg (1 capsule) 2 times a day on a regular basis.
Daily treatment with Celebrex helps to slow down the progression of this disease significantly. In a clinical study, 205 patients took celecoxib in a dose of 200 mg per day for two years. Half of them took it daily while the other half took it when they needed to stop the pain. The results showed that the patients who took Celebrex daily showed twice as less deterioration compared to the patients who took it as needed.
Celecoxib is the only selective NSAID approved for use in the US. It is approved and recommended for the treatment standards for many diseases in Europe.